By Chi-Chao Chan
This publication describes experimental animal versions that mimic universal human ocular ailments: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ ailment, and intraocular tumors. In conjunction, those versions mirror the range and software of instruments used to review human illness. global specialist clinicians talk about each one version in accordance with their medical event and the textual content is supported by means of a number of pictures and diagrams. In describing the main pertinent animal types of ophthalmic illnesses, this e-book could be of curiosity to ophthalmologists, imaginative and prescient researchers, fellows, citizens and clinical students.
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Extra info for Animal Models of Ophthalmic Diseases
Surv Ophthalmol 51(1):51–62. 1016/j. 005 Gwon A (2008) The rabbit in cataract/IOL surgery. In: Tsonis P (ed) Animal models in eye research. Elsevier, New York Halder N, Joshi S, Gupta SK (2003) Lens aldose reductase inhibiting potential of some indigenous plants. J Ethnopharmacol 86(1):113–116 Hales AM, Schulz MW, Chamberlain CG, McAvoy JW (1994) TGF-beta 1 induces lens cells to accumulate alpha-smooth muscle actin, a marker for subcapsular cataracts. Curr Eye Res 13(12):885–890 Hansen L, Yao W, Eiberg H, Kjaer KW, Baggesen K, Hejtmancik JF, Rosenberg T (2007) Genetic heterogeneity in microcornea-cataract: five novel mutations in CRYAA, CRYGD, and GJA8.
2010). UVA and UVB have also been shown to directly damage lens proteins both in vivo and in vitro (Giblin et al. 2002; Simpanya et al. 2008). Most recent work using the UVBinduced rat model has focused on determining potential anti-cataract/protective agents. For example, caffeine has been shown to have in vitro and in vivo protective effects against UVB irradiation in rats (Kronschlager et al. 2013; Varma et al. 2008). The lens contains a high concentration of reduced glutathione (GSH), which acts to eliminate oxidants and protect against exogenous and endogenous ROS.
Genomics 36(1):171–173. 0439 Cherfan GM, Michels RG, de Bustros S, Enger C, Glaser BM (1991) Nuclear sclerotic cataract after vitrectomy for idiopathic epiretinal membranes causing macular pucker. Am J Ophthalmol 111(4):434–438 Colucci-Guyon E, Portier MM, Dunia I, Paulin D, Pournin S, Babinet C (1994) Mice lacking vimentin develop and reproduce without an obvious phenotype. Cell 79(4):679–694 Coulombre AJ, Coulombre JL (1964) Lens development. I. Role of the lens in eye growth. J Exp Zoology 156:39–47 Davidson MG, Wormstone M, Morgan D, Malakof R, Allen J, McGahan MC (2000) Ex vivo canine lens capsular sac explants.
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